ビフィズス菌研究所

 

ビフィズス菌BB536に関する主な研究論文

Iwabuchi N. et al, ｢Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions｣. FEMS Immunol Med Microbiol, 55(3):324-34 (2009)

Odamaki T. et al, ｢Distribution of different species of the Bacteroides fragilis group in individuals with Japanese cedar pollinosis｣. Appl Environ Microbiol, 74 (21):6814-7（2008）

Abe F. et al, ｢Stability of bifidobacteria in powdered formula｣. Int J Food Sci Technol, 44(4): 718-724 (2009)

Abe F. et al, ｢Effects of storage temperature and water activity on the survival of bifidobacteria in powder form｣. Int J Dairy Technol, 62(2): 234-239 (2009)

Matsumoto T. et al, ｢Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice｣. J Appl Microbiol, 104(3): 672-80 (2008)

Kabeir BM. et al, ｢Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice｣. Lett Appl Microbiol, 46: 32-7 (2008)

Odamaki T. et al, ｢Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season｣. J Med Microbiol, 56: 1301-8 (2007)

Iwabuchi N. et al, ｢In vitro Th1 cytokine-independent th2 suppressive effects of bifidobacteria｣. Microbiol Immunol, 51(7): 649-60 (2007)

Xiao JZ. et al, ｢Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit｣. Allergology International, 56(1): 67-75 (2007)

Xiao JZ. et al, ｢Changes in plasma TARC levels during Japanese cedar pollen season and relationships with symptom development｣. Int Arch Allergy Immunol, 144(2): 123-127 (2007)

Odamaki T. et al, ｢Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake｣. J Investig Allergol Clin Immunol, 17(2): 92-100 (2007)

Sairanen U. et al, ｢The effect of probiotic fermented milk and inulin on the functions and microecology of the intestine｣. J Dairy Res, 74(3): 367-373 (2007)

Puccio G. et al, ｢Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics｣. Nutrition, 23: 1-8 (2007)

清水（肖）金忠ら, ｢Bifidobacterium longum BB536含有ドリンクタイプヨーグルト摂取による便秘傾向健常者の排便回数および排便性状に及ぼす影響｣. Jpn.J. Lactic Acid Bact, 18(1): 31-36 (2007)

Mah KW. et al, ｢Effect of a milk formula containing probiotics on the fecal microbiota of asian infants at risk of atopic diseases｣. Pediatr Res. 2007 Dec;62(6):674-9

Xiao JZ. et al, ｢Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial｣. Clinical and Experimental Allergy, 36: 1425-1435 (2006)

Xiao JZ. et al, ｢Effect of probiotic Bifidobacterium longum BB536 in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial｣. J Investing Allergol Clin Immunol, 16(2): 86-93 (2006)

Takahashi N. et al, ｢Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model｣. Biosci. Biotechnol. Biochem, 70(8): 2013-2017 (2006)

Takahashi N. et al, ｢Immunostimulatory oligodeoxynucleotide from Bifidobacterium longum suppresses Th2 immune responses in a murine model｣. Clinical and Experimental Immunology, 145: 130-138 (2006)

Takahashi N. et al, ｢An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro｣. FEMS Immnol Med Microbiol, 46: 461-469 (2006)

van der Meulen R. et al, ｢In vitro kinetic analysis of oligofructose consumption by Bacteroides and Bifidobacterium spp. indicates different degradation mechanisms｣. Appl Environ Microbiol, 72(2): 1006-1012 (2006)

van der Meulen R. et al, ｢Kinetic analysis of Bifidobacterial metabolism reveals a minor role for succinic acid in the regeneration of NAD+ through its growth-associated production｣. Appl Environ Microbiol, 72(8): 5204-5210 (2006)

Makras L and de Vuyst L., ｢The in vitro inhibition of Gram-negative pathogenic bacteria by bifidobacteria is caused by the production of organic acids｣. Int. Dairy Journal, 16: 1049-1057 (2006)

Falony G. et al, ｢Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose｣. Appl Environ Microbiol, 2(12): 7835-7841 (2006)

Kabeir BM. et al, ｢Growth of Bifidobacterium longum BB536 in medida (fermented cereal porridge) and their survival during refrigerated storage｣. Lett Appl Microbiol. 41: 125-31 (2005)

Zsivkovits M. et al, ｢Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different Lactobacillus strains｣. Carcinogenesis, 24: 1913-1918 (2003)

Namba K. et al, ｢Inhibitory effects of Bifidobacterium longum on enterohemorrhagic Escherichia coli O157:H7｣. Bioscience Microflora, 22(3) : 85-91 (2003)

八重島智子ら, ｢Bifidobacterium longum BB536を含む非発酵乳酸菌飲料の排便回数および便性状に及ぼす影響｣. 健康・栄養食品研究、4(2) : 1-6 (2001)

Fandi KG. et al, ｢Purification and N-terminal amino acid sequence of fructose-6-phosphate phosphoketolase from Bifidobacterium longum BB536｣. Lett Appl Microbiol. 32(4):235-9 (2001)

Ogata T. et al, ｢Effect of Bifidobacterium longum BB536 yogurt administration on the intestinal environment of healthy adults.｣. Microbial Ecology in Health and Disease, 11: 41-46 (1999)

八重島智子ら, ｢Bifidobacterium longum BB536含有加糖ヨーグルトの排便回数および排便性状に対する影響｣. 健康・栄養食品研究、1(3/4) : 29-34 (1998)

Yaeshima T. et al, ｢Effect of yogurt containing Bifidobacterium longum BB536 on the intestinal environment, fecal characteristics and defecation frequency.｣. Bioscience Microflora, 16: 73-77 (1997)

Singh J. et al, ｢Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis｣. Carcinogenesis, 18: 833-841(1997)

Ogata T. et al, ｢Effect of Bifidobacterium longum BB536 administration on the intestinal environment, defecation frequency and fecal characteristics of human volunteers.｣. Bioscience Microflora, 16 : 53-58 (1997)

Challa A. et al, ｢Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats｣. Carcinogenesis, 18: 517-521 (1997)

Tahri K. et al, ｢Effects of three strains of bifidobacteria on cholesterol｣. Letters in Applied Microbiology, 21: 149-151 (1995)

Grill JP. et al, ｢Effect of bifidobacteria on nitrites and nitrosamines｣. Letters in Applied Microbiology, 20: 328-330 (1995)

Grill JP. et al, ｢Characterization of fructose 6 phosphate phosphoketolases purified from Bifidobacterium species｣. Current Microbiology, 31: 49-54 (1995)

Grill JP. et al, ｢Bifidobacteria and probiotic effects: action of Bifidobacterium species on conjugated bile salts｣. Current Microbiology, 31: 23-27 (1995)

Grill JP. et al, ｢Purification and Characterization of Conjugated Bile Salt Hydrolase from Bifidobacterium longum BB536.｣. Appl Environ Microbiol. 61(7): 2577-2582 (1995)

Crociani J. et al, ｢Adhesion of different bifidobacteria strains to human enterocyte-like Caco-2 cells and comparison with in vivo study｣. Letters in Applied Microbiology, 21:146-148 (1995)

Araya-Kojima T. et al, ｢Inhibitory effects of Bifidobacterium longum BB536 on harmful intestinal bacteria｣. Bifidobacteria Microflora, 14(2) : 59-66 (1995)

秋山和範ら, ｢超未熟児におけるビフィズス菌の効果―Bifidobacterium breve投与による腸内細菌叢の変化｣. 日本新生児学会雑誌、 30(1) : 130-137 (1994)

秋山和範ら, ｢超未熟児におけるビフィズス菌の効果：Bifidobacterium longum投与による腸内フローラの変化（Bifidobacterium breveとの比較）｣. 日本新生児学会雑誌、 30(2): 257-263 (1994)

Sekine K. et al, ｢Comparison of the TNF-αlevels induced by human-derived Bifidobacterium longum and rat-derived Bifidobacterium animalis in mouse peritoneal cells｣. Bifidobacteria Microflora, 13(2): 79-89 (1994)

Orrhage K. et al, ｢Effect of supplements with Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin｣. Microbiol Ecology Health & Disease, 7:17-25 (1994)

Kulkarni N and Reddy BS., ｢Inhibitory effect of Bifidobacterium longum cultures on the Azoxymethane-induced aberrant crypt foci formation and fecal bacterialβ-glucuronidase｣. Proc Soc Exp Biol Med, 207: 278-283 (1994)

五十嵐 稔ら, ｢ビフィズス菌及びラクチュロースの卵巣摘出骨粗鬆症モデルラットの大腿骨に対する骨強度増強効果｣. ビフィズス、(2): 139-147 (1994)

Reddy BS and Rivenson A., ｢Inhibitory effect of Bifidobacterium longum on colon, mammary and liver carcinogenesis induced by 2-amino-3-methylimidazo [4,5-f ] quinoline, a food mutagen｣. Cancer Research, 53: 3914-3918 (1993)

Ballongue J. et al, ｢Action sur la flore intestinale de laits fermentes au Bifidobacterium｣. Lait, 73: 249-256 (1993)

Bennet R. et al, ｢Transient colonization of the gut of newborn infants by orally administered bifidobacteria and lactobacilli｣. Acta Paediatr, 81: 784-787 (1992)

Yamazaki S. et al, ｢Immune response of Bifidobacterium-monoassociated mice｣. Bifidobacteria Microflora, 10(1): 19-31 (1991)

Tomoda T. et al, ｢Effect of yogurt and yogurt supplemented with Bifidobacterium and/or lactulose in healthy persons: a comparative study｣. Bifidobacteria Microflora, 10(2): 123-130 (1991)

友田恒典ら, ｢健常者に対するBifidus菌含有ヨーグルト投与経験｣. ビフィズス、4: 21-24 (1990)

Tomoda T. et al, ｢Intestinal Candida overgrowth and Candida infection in patients with leukemia: effect of Bifidobacterium administration｣. Bifidobacteria Microflora, 7(2): 71-74 (1988)

陰山 克ら, ｢Bifidus菌含有製品の経口投与の比較検討｣. 医学と生物学、115(2) : 65-68 (1987)

Colombel JF. et al, ｢Yogurt with Bifidobacterium longum reduces erythromycin-induced gastrointestinal effects｣. The Lancet, II (8549): 43 (1987)

Ueda K. et al, ｢Immunity provided by colonized enteric bacteria｣. Bifidobacteria Microflora, 5(1): 67-72 (1986)

関根勇夫ら, ｢ビフィズス菌含有TM-1 milkの末梢血白血球化学発光、ならびに赤血球MCVに及ぼす影響―ビフィズス菌によるマクロファージの活性化｣. 治療学、14(5): 691-695 (1985)

海老沢悦子ら, ｢産婦人科入院患者へのビフィズス菌入りヨーグルト"ラ・サンテ"の使用経験｣. 臨床栄養、 66(7): 805-810 (1985)

Yamazaki S. et al, ｢Immunological responses to monoassociated Bifidobacterium longum and their relation to prevention of bacterial invasion｣. Immunology, 56: 43-50 (1985)

Kageyama T. et al, ｢The effect of Bifidobacterium administration in patients with leukemia｣. Bioscience Microflora, 3(1): 29-33 (1984)

Yamazaki S. et al, ｢Protective effect of Bifidobacterium-monoassociation against lethal activity of Escherichia coli｣. Bifidobacteria Microflora, 1(1) : 55-59 (1982)

友田恒典ら, ｢抗癌剤、免疫抑制剤投与時の少数常住腸内細菌の変動｣. 医学と生物学、103(1): 45-49 (1981)

百瀬寛資ら, ｢Bifidobacterium longum BB-536の毒性試験｣. 応用薬理、 17(5): 881-887 (1979)

関 増爾ら, ｢ビフィダスミルクによる高齢者の排便回数および糞便内ビフィダス菌数におよぼす影響｣. 栄養と食糧、31(4): 379-387 (1978)